Both belong to lineage 1 of GC1 indicating that strains belonging to lineage 1 are also present in the country. Tn 6018 copies are shown using dark green.Next
They are resistant to sulfamethoxazole, tetracycline, gentamicin, amikacin, third-generation cephalosporins and carbapenems.
The whole genome sequences of ABH008 and ABS200 were determined using the Illumina HiSeq X Ten platform. Despite being isolated in different hospitals, phylogenetic analysis indicated they are closely related. COM, PEKANBARU - Sedang trend JJ digunakan anak muda di twitter dan TikTok, lantas dan? Introduction Resistance to carbapenems in Acinetobacter baumannii, the number one WHO priority pathogen, is widespread, posing a global threat as carbapenems are the frontline option for treating infections caused by multi-antibiotic-resistant strains of this opportunistic pathogen.
Antibiotic resistance genes are shown using red arrows.
Here, we report analysis of whole genome sequence data for two antibiotic-resistant A. Methods Antibiotic resistance phenotype and PCR mapping Antibiotic resistance profiles of ABS200 and ABH008 were determined using the standard Kirby-Bauer disc diffusion assay to 28 antibiotics as previously described.Next
The presence of AbaR31 in both ABH008 and ABS200 indicates their close relationship as well as transmission between hospitals.
Two terminal vertical lines indicate the inverted repeats IRs of AbaR31..
Hence, they are considered extensively drug resistant XDR.
Genomes were annotated using the NCBI Prokaryotic Genome Annotation Pipeline v. The thick central line shows the chromosomes and horizontal arrows indicate the extent and orientation of genes.Next
The plasmid pA1-1 and its variants encode the AbkA pfam14384 and AbkB pfam04365 toxin—antitoxin system, which helps plasmids to be stably maintained in the cells.
Schematic representation of the ampC region in ABH008 and ABS200 compared with A1 GenBank accession number and 5457 GenBank accession number. The oxa23 gene is in Tn 2006 in AbaR4; this was confirmed by retrieving all of the contigs making up the complete AbaR4 from draft genomes. PCR conditions were the same as those described elsewhere.Next
We recently reported analysis of whole genome sequence data from an outbreak in an Iranian hospital that supports the view that lineage 2 GC1 strains may have an origin in the region.